Development of a multiparametric (bio)sensing platform for continuous monitoring of stress metabolites

There is a growing need for real-time monitoring of metabolic products that could reflect cell damages over extended periods. In this paper, we report the design and development an original multiparametric (bio)sensing platform tailored metabolites derived from cultures. Most attractive features our developed electrochemical are its easy manufacturing process, enables seamless scale-up, modular versatile approach, low cost. addition, allows analysis instead single-analyte analysis. Here provide overview sensors-based four main factors can indicate possible deterioration problem during cell-culture: pH, hydrogen peroxide, nitric oxide/nitrite lactate. Herein, proposing sensors based on thick-film coupled to microfluidic technology be integrated into any system using Luer-lock connectors. This obtaining accurate secreting stress cell/tissues culture.